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International Journal of Pharmacognosy and Herbal Drug Technology

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📢 Latest Update: New special issue call for papers on "Pharmacognosy and Herbal Drug Technology" - Submit by March 31, 2026

📢 Latest Update: New special issue call for papers on "Pharmacognosy and Herbal Drug Technology" - Submit by March 31, 2026

Volume 2, Issue 4 - 2025 (IJPHDT, Vol-2, Issue-4, April-2025)

Volume 2 Issue 4 Cover

Issue Details:

Volume 2 Issue 4
Published:Invalid Date

Editorial: IJPHDT, Vol-2, Issue-4, April-2025

Welcome to the 2025 issue of International Journal of Pharmacognosy and Herbal Drug Technology. This issue showcases the remarkable breadth and depth of contemporary research across multiple disciplines. From cutting-edge applications of machine learning in climate science to the revolutionary potential of quantum computing in drug discovery, our featured articles demonstrate the power of interdisciplinary collaboration in addressing global challenges.

We are particularly excited to present research that bridges traditional academic boundaries, reflecting our journal's commitment to fostering innovation through cross-disciplinary dialogue. The integration of artificial intelligence with environmental science, the application of blockchain technology to supply chain management, and the convergence of urban planning with smart city technologies exemplify the transformative potential of collaborative research.

As we continue to navigate an era of rapid technological advancement and global challenges, the research presented in this issue offers both insights and solutions that will shape our future. We thank our authors, reviewers, and editorial board members for their continued dedication to advancing knowledge and promoting scientific excellence.

Dr. Arpan Kumar Tripathi
Editor-in-Chief
International Journal of Pharmacognosy and Herbal Drug Technology

Articles in This Issue

Showing 5 of 5 articles
Research PaperID: ijphdt-00000064

Pharmacodynamic Evaluation of Syzygium Cumini Extract in Experimental Diabetic Models

Hemkanti Patel, Neha Mandle

The experimental analysis of Syzygium cumini extract pharmacodynamic properties examines blood glucose control mechanisms and antioxidant effects and tests security parameters. For 28 days Wistar rats with streptozotocin-induced diabetes received Syzygium cumini extract treatment at both 200 mg/kg and 400 mg/kg doses. Blood glucose levels decreased substantially during the study period while the high-dose treatment group achieved near-normal glucose concentrations by its conclusion. The antioxidant function of the extract occurred due to elevated reduced glutathione (GSH) together with higher superoxide dismutase (SOD), catalase levels and decreased malondialdehyde (MDA). Tests of lipid profile showed higher HDL values and lower levels of total cholesterol and triglycerides and LDL which could protect the heart. The test of liver enzymes validated a good safety profile for the extract because it yielded negative hepatotoxicity results. Test outcomes demonstrate that Syzygium cumini extract may function as an additional treatment to manage diabetes together with its connected complications and protect the cardiovascular system.

4,540 views
1,323 downloads

Contributors:

 Hemkanti Patel
,
 Neha Mandle
Research PaperID: ijphdt-00000065

Evaluation of Sustained Release MatrixTablets Using Natural Polymers

Pratibha Sahu

The study evaluates sustained-release matrix tablets created from natural polymers alginate and guar gum and xanthan gum and chitosan when using model drugs diclofenac sodium and theophylline. The research determines the drug release patterns together with tablet physical measurements (hardness, friability, moisture content) and formulation comparability between sustained-release pharmaceuticals and conventional deliverysystems. The research used various matrix tablets  made from natural polymers for which in vitro drug releases were conducted with a dissolution testing apparatus. Drug release from alginate and xanthan gum matrices occurred through gradual kinetics leading to sustained drug outcome with zero-order patterns. The drug release from tablets containing guar gum and chitosan followed inconsistent behavior. Xanthan gum matrices demonstrated the highest level of hardness and lowest degree of friability among all physical characteristic measurements. All stability tests demonstrated formulation stability since the drug release profiles remained unmodified. Bioavailability tests demonstrated the sustainedrelease dosages released the drug into the body at a steadier and more delayed pace than standard pill tablets. The statistical evaluations confirmed that distinct dissimilarities appeared between different formulations regarding the release rate of drugs along with hardness characteristics and bioavailability parameters and the degree to which the formulations broke apart. The release profiles of sustained-release matrix tablets enhance when designed with natural polymers alginate and xanthan gum.

Lipid ProfileAntioxidant ActivityBlood Glucose RegulationDiabetesSyzygium cumini
4,780 views
1,303 downloads

Contributors:

 Pratibha Sahu
Research PaperID: ijphdt-00000066

Effect of Heavy Metals on Germination andGrowth of Trigonella Foenum-Graecum

Revendra Parganiha

Heavy metals like lead (Pb), cadmium (Cd), and chromium (Cr) are common environmental pollutants that constitute a major hazard to soil and plant health. The metals are known to inhibit plant growth and development, and they have implications for agriculture and food security. The present research seeks to explore the effect of these heavy metals on the germination and seedling growth of Trigonella foenum-graecum (fenugreek), a widely grown crop of both agricultural and medicinal value. The experiment, carried out under controlled laboratory conditions, subjected fenugreek seeds to different concentrations (0, 25, 50, 100, and 200 ppm) of each metal. The findings showed drastic reduction in seed germination percent, shoot and root growths, and vigor of the seedlings as concentration of heavy metal increased, but lead exhibited worst effects. Results highlight adverse influence of heavy metal pollution on the growth of plant, thereby bringing into perspective requirements for remediation measures against the environmental pollution for its detestable effect on agricultural produce.

Stability.BioavailabilityDrug release profilesNatural polymersSustained-release tablets
4,644 views
1,512 downloads

Contributors:

 Revendra Parganiha
Research PaperID: ijphdt-00000067

Development of Herbal-Based Nanoparticlesfor Enhanced Drug Delivery

Govind Sharma

This article thoroughly discusses the advancements and therapeutic potential of herbal-based nanoparticles as emerging drug delivery systems. Herbal nanoparticles, which were synthesized predominantly by using ecofriendly green synthesis methods incorporating plant extracts, have emerged as a better option compared to conventional drug carriers by enhancing solubility, stability, bioavailability, and facilitating targeted drug delivery. The report highlights the integration of bioactive phytochemicals such as flavonoids, alkaloids, and terpenoids into nanoparticle systems to improve the therapeutic efficacy against cancer, microbial infections, and chronic inflammation. Key characteristics addressed include the synthesis pathways, drug loading capacities, controlled and sustained release mechanisms, biocompatibility assessment, pharmacokinetic improvement, and toxicity evaluation. Moreover, the advantages of herbal-based nanoparticles on the environment, including their biodegradability, reduced ecological footprint, and reduced waste during production, are underscored as being pivotal in fueling green pharmaceutical technologies. Despite challenges like bulk production and stability over long periods already being faced, herbala-based nanoparticles offer a promising path to propel personalized medicine, enhance patient outcomes, and maintain pharmaceutical innovation. The review confirms that additional studies in herbal nanotechnology are potentially revolutionary to future therapeutic interventions and eco-friendly environmental healthcare interventions.

crop productivityenvironmental pollutionseedling vigorshoot lengthroot lengthgermination+5 more
4,647 views
1,451 downloads

Contributors:

 Govind Sharma
Research PaperID: ijphdt-00000068

Evaluation of Some Heavy MetalsConcentrations in Chocolate, Candies andTomato Puree

Revendra Parganiha

The paper deals with the evaluation of heavy metals like lead and cadmium concentration in chocolate, candy and tomato puree which leads to fatal disease. In this paper the emphasis will be given to the process how the adding process is done, how chocolate industry took shape in the global market and how deadly it can be if the chocolate bars are being taken again and again.

Environmental Sustainability.BiocompatibilityTargeted TherapyGreen SynthesisDrug DeliveryHerbal-Based Nanoparticles
4,810 views
1,513 downloads

Contributors:

 Revendra Parganiha

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