The experiment showed that herbal interventions yielded impressive clinical symptoms, brain activity, and genetic biomarkers expression changes in patients with schizophrenia. Significant changes in PANSS scores, increase in activity of the prefrontal cortex and hippocampus, and positive change in DISC1 and COMT genes suggest that the herbal preparations have significant neurobiological and molecular impact. Even though standard drug therapy was somewhat more effective, herbal therapy had significant therapeutic potential in comparison with the control group. Significance of the Study Recommendations Herbal preparations can be discussed as potentially effective adjunctive treatment in the treatment of schizophrenia. They can assist in enhancing clinical outcomes and decreasing restrictions that come with traditional therapies. Large-scale research is required to endorse the efficacy and dependability of herbal interventions. Long-term clinical trials: Long-term clinical trials are necessary to determine safety and long-term therapeutic effects. Future studies ought to consider more genetic biomarkers and mechanisms. To achieve wider clinical use and consistency, herbal formulations need to be standardized.