Peptic ulcer disease is a most common gastrointestinal ailment that cause mucosal erosion in the stomach or duodenum is most commonly induced by Helicobacter pylori infection, NSAIDs, stress, and lifestyle. Conventional therapies, including antibiotics and proton pump inhibitors effective, but causes potential side effects and recurrence risks. More focus has shifted towards complementary and alternative medicines, with special emphasis on herbal drugs and nutraceuticals because of their safety profile, cost-effectiveness, and comprehensive health benefits. Of these, Licoricey (Glycyrrhiza glabra) and Aloe vera have been shown to possess highly effective anti-ulcer effect. Licoricey contains autoprotective, anti-inflammatory, and anti-H. pylori activities, whereas Aloe vera provides wound healing, antioxidant, and cytoprotective actions to the gastric mucosa. This review discusses the mechanism, effectiveness, and possible therapeutic applications of these natural compounds in the treatment of peptic ulcers, noting their synergistic potential with standard treatments.