This study investigates the anti-ulcer potential of Osyris quadripartita leaf extract using albino Wistar rats as an experimental model. The extract was prepared by Soxhlet extraction with methanol and its efficacy was evaluated in both ethanol and indomethacin-induced ulcer models, which simulate different ulcerogenesis mechanisms. Rats were treated with varying doses of the extract (100, 200, and 400 mg/kg) for 7 days, alongside a standard group receiving omeprazole. The outcomes were assessed through gastric juice pH measurement, ulcer index scoring, and histological examination of gastric tissue. Results showed a dose-dependent reduction in ulcer severity and an increase in gastric pH, suggesting enhanced mucosal protection. The 400 mg/kg dose demonstrated comparable effectiveness to omeprazole. The study provides scientific evidence supporting the gastroprotective properties of Osyris quadripartita, highlighting its potential as a natural remedy for peptic ulcer.