The study presented here was designed to establish the efficacy and safety of herbal remedy treatments for stomach ulcers when compared to conventional medication. A mixed-methods research design using a randomized controlled trial was combined with qualitative interviews of patients. The sample was composed of 200 participants with a diagnosis of mild to moderate stomach ulcers, randomly assigned to either an experimental or control group. The herbal remedy group received a combination of Glycyrrhiza glabra, Aloe vera, Zingiber officinale, and Curcuma longa, while controls received standard PPIs or H2 receptor antagonists, along with antibiotics if H. pylori was present. Data were collected at baseline, 4 weeks, and 8 weeks, assessing ulcer healing rates, symptom relief, and side effects. No significant differences in ulcer healing rates were found between the two groups: 88% versus 82% after 8 weeks, p = 0.299. In both groups, there was a significant alleviation of symptoms: reduction of pain, bloating, and nausea; p = 0.001, 0.005, and 0.002, respectively. Side effects were similar in both groups, with gastrointestinal discomfort being the most frequent but not significantly different between the groups, p = 0.365. Qualitative data, through interviews among the patients, showed that 60% of the patients preferred herbal remedies because of lesser side effects and a more natural approach to the treatment of their ailment. This study is, therefore, conclusive that herbal remedies are equally effective and safe as conventional treatments in managing stomach ulcers, although most patients have expressed preference for the former.