The study evaluates sustained-release matrix tablets created from natural polymers alginate and guar gum and xanthan gum and chitosan when using model drugs diclofenac sodium and theophylline. The research determines the drug release patterns together with tablet physical measurements (hardness, friability, moisture content) and formulation comparability between sustained-release pharmaceuticals and conventional deliverysystems. The research used various matrix tablets  made from natural polymers for which in vitro drug releases were conducted with a dissolution testing apparatus. Drug release from alginate and xanthan gum matrices occurred through gradual kinetics leading to sustained drug outcome with zero-order patterns. The drug release from tablets containing guar gum and chitosan followed inconsistent behavior. Xanthan gum matrices demonstrated the highest level of hardness and lowest degree of friability among all physical characteristic measurements. All stability tests demonstrated formulation stability since the drug release profiles remained unmodified. Bioavailability tests demonstrated the sustainedrelease dosages released the drug into the body at a steadier and more delayed pace than standard pill tablets. The statistical evaluations confirmed that distinct dissimilarities appeared between different formulations regarding the release rate of drugs along with hardness characteristics and bioavailability parameters and the degree to which the formulations broke apart. The release profiles of sustained-release matrix tablets enhance when designed with natural polymers alginate and xanthan gum.