The current work used the carrageenan-induced paw edema model in Wistar rats to determine the anti-inflammatory properties of plant-based substances, namely quercetin (Ficus carica) and curcumin (Curcuma longa). Four groups of 24 rats each were created: Quercetin, Curcumin, Standard Drug (Diclofenac), and Negative Control. The volume of paw edema was measured one, two, three, and four hours after induction. Diclofenac showed the greatest suppression of paw swelling at all time periods, while carrageenan was able to successfully produce inflammation in the control group, according to the results. When compared to the control, both curcumin and quercetin considerably decreased inflammation; however, the difference was not statistically significant, with curcumin being slightly more efficient than quercetin. The trustworthiness of these findings was validated by statistical analysis. According to the study's findings, quercetin and curcumin have strong anti-inflammatory properties and could be useful natural supplements or substitutes for traditional synthetic medications.