Hyperlipidemia is a major contributor to cardiovascular diseases. The present study evaluates the anti-hyperlipidemic potential of Capsicum chinense Jacq. fruit extract in high-fat diet (HFD) induced hyperlipidemic rats. Rats were divided into six groups including Normal Control, HFD Control, Standard (Atorvastatin 7.2 mg/kg), and three test groups receiving extract doses of 5, 7.5, and 10 mg/kg respectively. Significant reductions (pCapsicum chinense as a promising natural hypolipidemic agent.