Antioxidant

Gingivitis is a more common and reversible periodontal disease that mostly happens due to dental plaque build-up and such a periodontal disease is mostly treated using chemical mouthwashes like chlorhexidine, but despite its use in the prevention of the disease, the use of such type of mouthwashes is usually linked to several undesirable side effects. It was a multi-center randomized controlled clinical trial that assessed the safety and effectiveness of herbal mouthwash standardized to prevent gingivitis. Two hundred individuals who had mild to moderate gingivitis were selected in three dental care facilities and then randomly allocated into either the herbal mouthwash or control group to undergo 12 weeks of intervention. Clinical results were measured with the help of the Gingivar Index (GI) and the Plaque Index (PI) at baseline, 4, 8, and 12 weeks and the safety and tolerability measured with the structured adverse-event reporting. The findings showed statistically significant and progressive depressing effects of the herbal mouthwash group on both GI and PI scores relative to the control group at all intervals of the follow-up (p

Western Ghats in India which has been globally accepted as a World Heritage Site by UNESCO serves as a hotspot of biological diversity, having a rich diversity of endemic medicinal plants with pharmacological value. The purpose of the current literature was to isolate and characterize new bioactive agents in some of the endemic plants, Coscinium fenestratum, Plectranthus vettiveroides and Garcinia indica. The used plant materials were obtained with a professional and ethical standard of collection of both conservation and ethical standards, extracted via solvent partitioning and then chromatographically separated. The presence of that structure was elucidated by Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR) and high-resolution mass spectrometry ( HR MS) analysis. Screening of the bioactivity was done on antimicrobial, anticancer and antioxidant activities. It was found that there were three new alkaloids plus two flavonoid glycosides and a hitherto unknown Xanthone derivative. Such substances demonstrated a strong in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli, high antioxidant properties in assays of DPPH and ABTS, and selective human breast cancer cell lines cytotoxicity (MCF-7). These results add to the fact that the flora of the Western Ghats has significant potential in novel drug discovery.